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Article

Macrophages expressing macrophage receptor with collagen structure attenuate liver fibrosis through a tissue restoration phenotype.

JCI insight - 23 Mar 2026

Jerez Sofia, Cooper Shawna A, Yaqoob Usman, Kalaiger Maleeha F, Anwar Abid A, Wong Mandy, Arif Bushra, Doskey Luke C, Hernandez-Tejero Maria, Sherman William A, De Boeck Ruben, Li Ying, Hilscher Moira B, Kostallari Enis, Jalan-Sakrikar Nidhi, Cao Sheng, Shah Vijay H

Abstract excerpt

Liver macrophages are central in maintaining hepatic homeostasis and mediating immune responses during liver injury, including fibrosis. Macrophages may have proinflammatory or antiinflammatory properties, but which properties influence fibrosis remains unclear. To explore the role of macrophages in liver fibrosis, we performed single-cell RNA-seq in a mouse model of liver injury and found that macrophage...

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Share to Collagen
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41869728
DOI: 10.1172/jci.insight.193172
PMCID: PMC13043091

Genes

MARCO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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