Multivariate Survival Analysis of a Comprehensive Clinical Trial of Rapamycin in Amyotrophic Lateral Sclerosis Explores Prognostic Factors and Survival Patterns in C9orf72 Carriers.

doi:10.1111/ene.70756

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Article

Multivariate Survival Analysis of a Comprehensive Clinical Trial of Rapamycin in Amyotrophic Lateral Sclerosis Explores Prognostic Factors and Survival Patterns in C9orf72 Carriers.

European journal of neurology - 1 Sept 2026

De Nardi Alex, Paris Alessio, Lauria Mario, Martinelli Ilaria, Zucchi Elisabetta, Simonini Cecilia, Mandrioli Jessica, Marchetti Luca

Abstract excerpt

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease marked by considerable variability in survival times. This retrospective study aims to evaluate the prognostic value of a broad range of variables by conducting a comprehensive survival analysis on longitudinal data from RAP-ALS, a clinical trial investigating the effects of rapamycin in ALS patients (n = 63). METHODS:...

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Topics

Humans
Amyotrophic Lateral Sclerosis
C9orf72 Protein
Female
Male
Prognosis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Sirolimus

Middle Aged

Survival Analysis

Retrospective Studies

Multivariate Analysis

Aged

Mutation

Heterozygote

Adult

Immunosuppressive Agents

Source

Open in PubMed Open full text

Identifiers

PMID: 42760861
DOI: 10.1111/ene.70756
PMCID: PMC13589253

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