Article
Progress, development, and challenges in amyotrophic lateral sclerosis clinical trials.
Expert review of neurotherapeutics - 1 Jan 2000
Ashhurst Jasmine F, Tu Sicong, Timmins Hannah C, Kiernan Matthew C
Abstract excerpt
INTRODUCTION: Amyotrophic Lateral Sclerosis (ALS) brings unique challenges to a clinical trial setting, due in part to relatively low disease prevalence coupled with a poor prognosis, in addition to the complexities linked to disease heterogeneity. As critical understanding of the disease develops, particularly in relation to clinical phenotype and the mechanisms of disease progression, so too new concepts evolve...
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