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Article

Mathematical dissection of tumor phenotypic heterogeneity in a spatial data-informed nonlocal reaction-diffusion model.

Journal of mathematical biology - 22 Mar 2026

Li Fang, Li Hui, Lin Ling, Sun Xiaoqiang

Abstract excerpt

Intratumor phenotypic heterogeneity plays a pivotal role in shaping the evolutionary dynamics of tumor growth and drug responses. Nonlocal reaction-diffusion equations have been developed to model the spatio-temporal dynamics of tumor cells with heterogeneous phenotypes. However, rigorous mathematical analysis of such nonlocal reaction-diffusion equations with high spatial and phenotypic dimensions remains...

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PMID: 41866589
DOI: 10.1007/s00285-026-02380-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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