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Article

Inhibition of fibroblast activation protein partially restores the homeostatic phenotype of mechanoactivated synoviocytes.

Osteoarthritis and cartilage - 1 Jul 2026

Bernstein Elizabeth R, Stoeckl Brendan D, Flaugh Rachel, Laforest Lorielle, Burt Kevin G, Dyment Nathaniel A, Scanzello Carla R, Mauck Robert L, Miller Liane

Abstract excerpt

OBJECTIVE: Synovial fibrosis, characterized by mechanoactivation of fibroblast-like synoviocytes (FLS), is thought to be a driver of osteoarthritis (OA). Fibroblast activation protein (FAP) is expressed by activated FLS and contributes to OA progression, but the mechanisms by which it does so are undefined. The objective of this study was to evaluate FAP expression in OA across species, assess FAP regulation in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41865972
DOI: 10.1016/j.joca.2026.03.121
PMCID: PMC13360769

Genes

FAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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