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Analysis of the NLRP3 inflammasome components expression in triple-negative breast cancer patients with and without BRCA1 mutations.

Scientific reports - 21 Mar 2026

Faria Sara Socorro, Costantini Susan, Di Gennaro Elena, de Lima Vladmir C Cordeiro, Andrade Victor Piana, de Pádua Cristiano, Duval Vinícius, Marques Marcia Maria Chiquitelli, Magalhães Kelly Grace

Abstract excerpt

Triple-negative breast cancer (TNBC) is an aggressive and immunogenic breast cancer subtype frequently associated with BRCA1 alterations. Inflammation and innate immune sensing pathways, including inflammasomes, play complex and context-dependent roles in tumor progression and anti-tumor immunity. However, the prognostic significance of inflammasome components in TNBC remains poorly defined. We evaluated the...

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BRCA1 Protein
CARD Signaling Adaptor Proteins
Caspase 1
Inflammasomes
Interleukin-18

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kaplan-Meier Estimate

NLR Family, Pyrin Domain-Containing 3 Protein

Triple Negative Breast Neoplasms

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Open in PubMed Open full text

Identifiers

PMID: 41865075
DOI: 10.1038/s41598-026-43392-0
PMCID: PMC13181052

Genes

NLRP3
BRCA1
CASP1
PYCARD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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