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Article

ZNF831 suppresses triple-negative breast cancer progression through NLRP3-associated pyroptotic signaling and M1-like macrophage phenotypic remodeling.

Breast cancer research : BCR - 23 May 2026

Liu Qingqing, Fan Jun, Peng Wantao, Deng Shuangwu, Tan Yupei, Guo Fei, Zhong Jiangxue, Zhou Shimeng, Liu Wenbin, Xu Yan

Abstract excerpt

BACKGROUND: Triple-negative breast cancer (TNBC) remains difficult to treat because of poor immunogenicity and an immunosuppressive tumor microenvironment (TME). Pyroptotic signaling can enhance antitumor immunity through inflammatory cytokine release, but upstream regulators linking this process to macrophage phenotypic remodeling in TNBC remain incompletely understood. We investigated whether zinc finger...

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Share to Cell Line, Tumor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

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Share to NLR Family, Pyrin Domain-Containing 3 Protein

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Source

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Identifiers

PMID: 42177558
DOI: 10.1186/s13058-026-02307-7
PMCID: PMC13390289

Genes

ZNF831
NLRP3
MB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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