Article
Genetic architecture and phenotypic diversity of oocyte and early embryo competence defects in female infertility.
Nature medicine - 1 Jan 2026
Zhang Changlong, Zheng Wei, Zhang Honghui, Zhao Shuai, Hu Huiling, Xu Xilin, Wan Xian, Sun Jiaqi, Su Wei, Wang Yang, Cui Ying, Yang Bohan, Yin Changjian, Zhang Xin, Li Cheng, Zhang Xin, Zhang Changming, Wang Zhao, Yuan Ying, Liu Liu, Meng Fei, Zhang Jiangtao, Cao Yongzhi, Gao Yuan, Zhao Shigang, Gong Fei, Wu Keliang, Zhang Feng, Tang Shuyan, Lin Ge, Zhao Han, Chen Zi-Jiang
Abstract excerpt
Oocyte and early embryo competence defects (OECD) represent a recently recognized cause of female infertility with the application of assisted reproductive technology, characterized by impaired oocyte or early embryo development. To investigate the genetic landscape and subtypes of OECD, we performed whole-exome sequencing on 2,140 patients, classifying them into six distinct subtypes. We identified 183...
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