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Article

Locking the dimeric GABA(B) G-protein-coupled receptor in its active state.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 14 Jan 2004

Kniazeff Julie, Saintot Pierre-Philippe, Goudet Cyril, Liu Jianfeng, Charnet Annie, Guillon Gilles, Pin Jean-Philippe

Abstract excerpt

G-protein-coupled receptors (GPCRs) play a major role in cell-cell communication in the CNS. These proteins oscillate between various inactive and active conformations, the latter being stabilized by agonists. Although mutations can lead to constitutive activity, most of these destabilize inactiv...

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Identifiers

PMID: 14724235
DOI: 10.1523/JNEUROSCI.3141-03.2004
PMCID: PMC6729975

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-14724235-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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