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Article

Global burden and causal analysis of LDL-C-related cardiovascular diseases: A GBD 2021 and Mendelian randomization study.

Nutrition, metabolism, and cardiovascular diseases : NMCD - 1 Jun 2026

Zhang Jiling, Wu Yandan, Zhang Yanyan, Gao Lu, Hu Yanwei

Abstract excerpt

BACKGROUND AND AIM: High low-density lipoprotein cholesterol (LDL-C) is a major risk factor for cardiovascular diseases (CVDs), contributing substantially to global disease burden. We aimed to quantify the global burden of LDL-C-related CVDs and establish causal relationships through integrated Global Burden of Disease(GBD) and Mendelian randomization(MR) analyses. METHODS AND RESULTS: We analyzed the impact of...

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PMID: 41862301
DOI: 10.1016/j.numecd.2026.104622

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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