Causal inference and mediating pathways of metabolic syndrome on calcific aortic valve stenosis: linkage disequilibrium score regression and two-sample, two-step mendelian randomization study.

Abstract excerpt

BACKGROUND: Current evidence regarding the role of Metabolic Syndrome (MetS) and its components in Calcific Aortic Valve Stenosis (CAVS) remains limited and inconsistent. To elucidate the causal relationship and investigate potential mediators, we conducted Linkage Disequilibrium Score Regression (LDSC) and two-sample as well as two-step Mendelian Randomization (MR) analyses. METHODS: Based on genome-wide...

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