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Article

Causal Associations of Obesity With Chronic Kidney Disease and Arterial Stiffness: A Mendelian Randomization Study.

The Journal of clinical endocrinology and metabolism - 18 Jan 2022

Ye Chaojie, Kong Lijie, Zhao Zhiyun, Li Mian, Wang Shuangyuan, Lin Hong, Xu Yu, Lu Jieli, Chen Yuhong, Xu Yiping, Wang Weiqing, Ning Guang, Bi Yufang, Xu Min, Wang Tiange

Abstract excerpt

CONTEXT: Observational studies have been associated obesity with chronic kidney disease (CKD) and arterial stiffness, but the causality remains unclear. OBJECTIVE: We aimed to investigate the causality of obesity with CKD and arterial stiffness using mendelian randomization (MR) analysis. METHODS: We genotyped 14 body mass index (BMI)-associated variants validated in East Asians in 11 384 Chinese adults. A...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34448477
DOI: 10.1210/clinem/dgab633

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