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Causal Inference of Metabolic Syndrome on Calcific Aortic Valve Stenosis: Linkage Disequilibrium Score Regression and Two-Sample, Two-Step Mendelian Randomization Analysis

2025-08-22

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<title>Abstract</title> <p> 1.1 Background This study aims to clarify the causal relationship between metabolic syndrome (MetS) and calcific aortic valve stenosis (CAVS) through Linkage Disequilibrium score regression (LDSC) and two-sample and two-step Mendelian randomization (MR). 1.2 Methods We conducted LDSC analysis and two-sample and two-step MR with Bayesian weighted MR validation using genome-wide associa...

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Literature Corpus work
ebffe2ee-451f-588b-966a-f2e0d07b13de
DOI
10.21203/rs.3.rs-7141693/v1
Open publication

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Causal Inference of Metabolic Syndrome on Calcific Aortic Valve Stenosis: Linkage Disequilibrium Score Regression and Two-Sample, Two-Step Mendelian Randomization AnalysisDOI 10.21203/rs.3.rs-7141693/v1
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