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Article

Investigating the genetics of hippocampal volume in older adults without dementia.

PloS one - 1 Jan 2015

Mather Karen A, Armstrong Nicola J, Wen Wei, Kwok John B, Assareh Amelia A, Thalamuthu Anbupalam, Reppermund Simone, Duesing Konsta, Wright Margaret J, Ames David, Trollor Julian N, Brodaty Henry, Schofield Peter R, Sachdev Perminder S

Abstract excerpt

Hippocampal atrophy is observed with ageing and age-related neurodegenerative disease. Identification of the genetic correlates of hippocampal volume (HV) and atrophy may assist in elucidating the mechanisms of ageing and age-related neurodegeneration. Using two community cohorts of older Caucasians we estimated the heritability of HV and examined associations of HV with previously identified single nucleotide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25625606
DOI: 10.1371/journal.pone.0116920
PMCID: PMC4308067

Genes

APOE
BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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