Article
Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study.
Genome medicine - 1 Dec 2020
Gudmundsdottir Valborg, Pedersen Helle Krogh, Mazzoni Gianluca, Allin Kristine H, Artati Anna, Beulens Joline W, Banasik Karina, Brorsson Caroline, Cederberg Henna, Chabanova Elizaveta, De Masi Federico, Elders Petra J, Forgie Ian, Giordano Giuseppe N, Grallert Harald, Gupta Ramneek, Haid Mark, Hansen Torben, Hansen Tue H, Hattersley Andrew T, Heggie Alison, Hong Mun-Gwan, Jones Angus G, Koivula Robert, Kokkola Tarja, Laakso Markku, Løngreen Peter, Mahajan Anubha, Mari Andrea, McDonald Timothy J, McEvoy Donna, Musholt Petra B, Pavo Imre, Prehn Cornelia, Ruetten Hartmut, Ridderstråle Martin, Rutters Femke, Sharma Sapna, Slieker Roderick C, Syed Ali, Tajes Juan Fernandez, Thomas Cecilia Engel, Thomsen Henrik S, Vangipurapu Jagadish, Vestergaard Henrik, Viñuela Ana, Wesolowska-Andersen Agata, Walker Mark, Adamski Jerzy, Schwenk Jochen M, McCarthy Mark I, Pearson Ewan, Dermitzakis Emmanouil, Franks Paul W, Pedersen Oluf, Brunak Søren
Abstract excerpt
BACKGROUND: The rising prevalence of type 2 diabetes (T2D) poses a major global challenge. It remains unresolved to what extent transcriptomic signatures of metabolic dysregulation and T2D can be observed in easily accessible tissues such as blood. Additionally, large-scale human studies are required to further our understanding of the putative inflammatory component of insulin resistance and T2D. Here we used...
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