Article
Selective impact on regulatory T cells with sustained functional phenotypes by the interleukin-2 mutein VIS171 in a nonhuman primate model.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 Jul 2026
Schiliró Davide, Tunbridge Matt, Brown Nolan J, Lopez Joshua, Tollison Tammy, Smith Ethan, Ladowski Joseph, Martinino Alessandro, Hu Meghan, Schwalb Allison, Yoon Janghoon, Belloni Rafaela, O'Neil John J, Robinson Luke N, Schachter Asher D, Babcock Gregory J, Oldach David, Peng Xinxia, Chung Hokyung Kay, Knechtle Stuart, Kwun Jean
Abstract excerpt
The interleukin-2 mutein, VIS171, was engineered to extend half-life and enhance selective binding and expansion of regulatory T cells (Tregs) expressing high levels of the trimeric interleukin-2 receptor. This study evaluated the effects of VIS171 on immune cell populations in nonhuman primates, focusing on its ability to selectively expand Tregs, and then characterized their phenotype during expansion and...
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