Genomic Heterogeneity and Exceptional Response to Dual Pathway Inhibition in Anaplastic Thyroid Cancer.

doi:10.1158/1078-0432.CCR-16-2154-T

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Article

Genomic Heterogeneity and Exceptional Response to Dual Pathway Inhibition in Anaplastic Thyroid Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2017

Gibson William J, Ruan Daniel T, Paulson Vera A, Barletta Justine A, Hanna Glenn J, Kraft Stefan, Calles Antonio, Nehs Matthew A, Moore Francis D, Taylor-Weiner Amaro, Wala Jeremiah A, Zack Travis I, Lee Thomas C, Fennessy Fiona M, Alexander Erik K, Thomas Tom, Janne Pasi A, Garraway Levi A, Carter Scott L, Beroukhim Rameen, Lorch Jochen H, Van Allen Eliezer M

Abstract excerpt

Purpose: Cancers may resist single-agent targeted therapies when the flux of cellular growth signals is shifted from one pathway to another. Blockade of multiple pathways may be necessary for effective inhibition of tumor growth. We document a case in which a patient with anaplastic thyroid carcinoma (ATC) failed to respond to either mTOR/PI3K or combined RAF/MEK inhibition but experienced a dramatic response...

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PMID: 27797976
DOI: 10.1158/1078-0432.CCR-16-2154-T
PMCID: PMC5393965

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BRAF

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