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Plasma metabolite association profiles for type 2 diabetes genetic clusters in Finnish men.

Diabetologia - 1 Jul 2026

Peng Ruyi, Liu Lei, Chu Xiaomeng, Xia Zhijie, Fu Qi, Silva Lilian Fernandes, Ji Xiaolong, Hu Xinxian, Liang Yuxi, Li Jack, Ryan Brady, Bose Debraj, Stringham Heather M, Morrison Jean, Wen Xiaoquan, Scott Laura J, Burant Charles F, Fauman Eric, Yang Tao, Boehnke Michael, Laakso Markku, Yin Xianyong

Abstract excerpt

AIMS/HYPOTHESIS: A recent study has suggested eight clusters of genetic variants associated with type 2 diabetes. We aimed to characterise metabolite associations for these eight clusters. METHODS: We constructed type 2 diabetes overall and cluster-partitioned polygenic risk scores (PRSs) in 10,015 Finnish men with 979 named plasma metabolites measured in Metabolon HD4 mass spectrometry platform. We evaluated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41848902
DOI: 10.1007/s00125-026-06710-9
PMCID: PMC13236824

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