Article
Single nucleotide polymorphisms located in TNFA, IL1RN, IL6R, and IL6 genes are associated with COVID-19 risk and severity in an Iranian population.
Cell biology international - 1 Jul 2022
Rokni Mohsen, Sarhadi Mohammad, Heidari Nia Milad, Mohamed Khosroshahi Leila, Asghari Somaye, Sargazi Saman, Mirinejad Shekoufeh, Saravani Ramin
Abstract excerpt
Cytokines play pivotal functions in coronavirus disease 2019 (COVID-19) pathogenesis. However, little is known about the rationale and importance of genetic variations associated with immune system responses, so-called "immunogenetic profiling." We studied whether polymorphisms of IL6, IL6R, TNFA, and IL1RN affect the disorder severity and outcome in patients infected with COVID19. We recruited 317 hospitalized...
Topics
- COVID-19
- Cytokines
- Genetic Predisposition to Disease
- Genotype
- Humans
- Interleukin 1 Receptor Antagonist Protein
- Interleukin-6
- Iran
- Polymorphism, Single Nucleotide
- Receptors, Interleukin-6