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Type 2 diabetes and its genetic susceptibility are associated with increased severity and mortality of COVID-19 in UK Biobank.

Communications biology - 24 Jan 2024

Lee Aeyeon, Seo Jieun, Park Seunghwan, Cho Youngkwang, Kim Gaeun, Li Jun, Liang Liming, Park Taesung, Chung Wonil

Abstract excerpt

Type 2 diabetes (T2D) is known as one of the important risk factors for the severity and mortality of COVID-19. Here, we evaluate the impact of T2D and its genetic susceptibility on the severity and mortality of COVID-19, using 459,119 individuals in UK Biobank. Utilizing the polygenic risk scores (PRS) for T2D, we identified a significant association between T2D or T2D PRS, and COVID-19 severity. We further...

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Identifiers

PMID: 38267566
DOI: 10.1038/s42003-024-05799-1
PMCID: PMC10808197

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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