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Article

BRAF mutant colorectal cancer: prognosis, treatment, and new perspectives.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Nov 2017

Sanz-Garcia E, Argiles G, Elez E, Tabernero J

Abstract excerpt

The MAPK cascade plays a crucial role in tumor cell proliferation and survival. Accumulating evidence suggests that mutations in the BRAF oncogene are not only associated with poor prognosis but also linked with less benefit when treated with anti-epidermal growth factor receptor antibodies in metastatic colorectal cancer (mCRC). Targeting this molecular aberration has thus become a matter of particular interest...

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Identifiers

PMID: 29045527
DOI: 10.1093/annonc/mdx401

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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