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Clinical features and mutation analysis of class 1/2/3 BRAF mutation colorectal cancer.

Chinese clinical oncology - 1 Feb 2024

Huang Yingying, Jia Wenzhuo, Zhao Gang, Zhao Yunbo, Zhang Shuai, Li Zhongkang, Wu Guoju

Abstract excerpt

BACKGROUND: BRAF (B-Raf proto-oncogene, serine/threonine kinase)-mutated colorectal cancer (CRC) still has poor prognostic. The efficacy of BRAF inhibitor is unpredictable just that intrinsic genetic complexity, immune microenvironment and partially unknown reason. Understanding the co-mutation mechanism can help improve treatment and follow-up strategies. METHODS: We retrospectively analyzed 35...

Topics

Humans
Female
Aged
Proto-Oncogene Proteins B-raf
Colorectal Neoplasms
Retrospective Studies
Prognosis
Mutation
Microsatellite Instability
Tumor Microenvironment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38372057
DOI: 10.21037/cco-23-117

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-38372057-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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