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Article

Stabilization of the H5 clade 2.3.4.4b hemagglutinin improves vaccine-elicited neutralizing antibody responses in mice.

Science translational medicine - 4 Mar 2026

Dosey Annie, Dadonaite Bernadeta, Gillespie Rebecca A, Leaf Elizabeth M, Vukovich Matthew J, McGowan Jackson, Grey Emily, Muramatsu Hiromi, Jun Rachel H J, Pardi Norbert, Kanekiyo Masaru, Bloom Jesse D, King Neil P

Abstract excerpt

Transmission of highly pathogenic avian influenza from H5 clade 2.3.4.4b has expanded in recent years to infect large populations of birds and mammals, heightening the risk of a human pandemic. Influenza viruses that are adapted to transmission in birds and a variety of mammals tend to have a less stable hemagglutinin (HA) than seasonal influenza viruses, enabling membrane fusion at comparatively higher pH...

Topics

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Antibodies, Neutralizing
Antibodies, Viral
Antibody Formation
Epitope Mapping
Hemagglutinin Glycoproteins, Influenza Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Influenza A Virus, H5N1 Subtype

Influenza Vaccines

Protein Stability

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Identifiers

PMID: 41779867
DOI: 10.1126/scitranslmed.aea8770
PMCID: PMC13108606

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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