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AdipoRon alleviates cerebral ischemic injury through AMPK-dependent microglial autophagy and phenotypic modulation.

Molecular and cellular neurosciences - 1 Jun 2026

Meng Lingbin, Wang Jiangong, Liu Bin, Sun Fengjiao, Yang Ming, Luan Haiyun, Yang Meizi, Xu Yong, Xu Yixiang, Yang Xidong, Yan Haijing

Abstract excerpt

Ischemic stroke is a leading cause of death and disability with limited therapeutic options. Neuroinflammation, particularly microglial activation and phenotypic modulation, plays a crucial role in ischemic cerebral injury. AdipoRon (APR), an adiponectin receptor agonist, shows neuroprotective effects, but its role in modulating microglial phenotypic states after ischemic stroke remains unclear. Using a transient...

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PMID: 41833595
DOI: 10.1016/j.mcn.2026.104079

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