Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

AARS2 R199C mutation induces lactylation-driven premature ovarian insufficiency phenotypes partially reversible by SIRT3.

Reproduction (Cambridge, England) - 5 Apr 2026

Zhang Hai-Hui, Zhang Zhi-Ling, Xu Wei

Abstract excerpt

In a homozygous alanine-tRNA synthetase 2 R194C knock-in mouse model (mimicking the human R199C -pathogenic variant), this study demonstrates that a single mutation can cause ovarian insufficiency in vivo and identifies the lactylation-metabolism-mechanistic target of rapamycin axis as the molecular driver of follicle exhaustion. Abstract Premature ovarian insufficiency (POI) often arises from genetic causes, yet...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acyl-tRNA Synthetases
Share to Gene Knock-In Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Ovarian Follicle

Share to Phenotype

Share to Primary Ovarian Insufficiency

Share to Sirtuin 3

Source

Identifiers

PMID: 41832996
DOI: 10.1093/reprod/xaag035

Genes

AARS2
SIRT3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

AARS2 R199C mutation induces lactylation-driven premature ovarian insufficiency phenotypes partially reversible by SIRT3.PMID 41832996Read ↗

BCAA insufficiency leads to premature ovarian insufficiency via ceramide‐induced elevation of ROSSemantic proximity Read ↗

Targeting autophagy in premature ovarian failure: Therapeutic strategies from molecular pathways to clinical applicationsSemantic proximity Read ↗

Loss of Carnitine Palmitoyltransferase 1a Reduces Docosahexaenoic Acid-Containing Phospholipids and Drives Sexually Dimorphic Liver Disease in MiceSemantic proximity Read ↗

Increased transport of acetyl-CoA into the endoplasmic reticulum causes a progeria-like phenotype.Semantic proximity Read ↗

Hepatocyte FAM210A deficiency disrupts mitochondrial function and triggers juvenile steatosis with compensatory repair in adulthoodSemantic proximity Read ↗

Hepatocyte FAM210A deficiency disrupts mitochondrial function and triggers juvenile steatosis with compensatory repair in adulthoodSemantic proximity Read ↗

POI-associated LMD-3 mutation impairs B12-regulated lysosomal function and reproductive capacity in <i>C. elegans</i>Semantic proximity Read ↗

PPM1K-regulated impaired catabolism of branched-chain amino acids orchestrates polycystic ovary syndromeSemantic proximity Read ↗

Selective Alanine Transporter Utilization Is a Therapeutic Vulnerability in ARID1A-Mutant Ovarian Cancer.Semantic proximity Read ↗

Beclin-1 deficiency in the murine ovary results in the reduction of progesterone production to promote preterm laborSemantic proximity Read ↗

Metabolic adaptation to maternal hyperglycemia via ACLY-dependent acetyl-CoA production drives epigenetic remodeling and dysregulated placental developmentSemantic proximity Read ↗

The SIRT5-SUCLG2 desuccinylation axis delays ovarian aging via a mitochondrial-epigenetic regulatory mechanismSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.