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Single-cell RNA sequencing provides insights into the potential cellular origins and microenvironment of Extramammary Paget's disease.

Clinical immunology (Orlando, Fla.) - 1 Jun 2026

Li Rui, Ren Feifei, Li Hongyang, Sun Qi, Ding Meilin, Li Dongqing, Cheng Wei, Chen Hao, Sun Jianfang, Jiang Mingjun, Wu Xinfeng, Huang Liming, Zhao Liang, Yang Yong, Zheng Meiling, Zhang Wei

Abstract excerpt

Extramammary Paget's disease (EMPD) is a frequently recurring malignant neoplasm with metastatic potential. The exact origin of the tumor is still undefined. To explore potential cellular origin-related signals and depict a relatively comprehensive cellular landscape of EMPD, we collected 50,180 cells from patients with EMPD. We detected a distinct basal keratinocyte cell population characterized by New York...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41831584
DOI: 10.1016/j.clim.2026.110698

Genes

MIF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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