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Article

Single-cell RNA sequencing captures patient-level heterogeneity and associated molecular phenotypes in breast cancer pleural effusions.

Clinical and translational medicine - 1 Sept 2023

Whitfield Holly J, Berthelet Jean, Mangiola Stefano, Bell Caroline, Anderson Robin L, Pal Bhupinder, Yeo Belinda, Papenfuss Anthony T, Merino Delphine, Davis Melissa J

Abstract excerpt

BACKGROUND: Malignant pleural effusions (MPEs) are a common complication of advanced cancers, particularly those adjacent to the pleura, such as lung and breast cancer. The pathophysiology of MPE formation remains poorly understood, and although MPEs are routinely used for the diagnosis of breast cancer patients, their composition and biology are poorly understood. It is difficult to distinguish invading...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37691350
DOI: 10.1002/ctm2.1356
PMCID: PMC10493486

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