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Article

Genomic landscape and homologous recombination deficiency in malignant germ cell tumors reveals sex-specific therapeutic opportunities.

The Journal of pathology - 1 Jun 2026

Xu Boheng, Chen Jiahong, Peng Huiting, Su Xuan, He Caiyun

Abstract excerpt

Malignant germ cell tumors (GCTs) are relatively rare tumors with limited therapeutic options. This study examined the homologous recombination deficiency (HRD) status and genomic characteristics in 14 patients with GCT who underwent next-generation sequencing. HRD was evaluated using the genomic instability score (GIS), which incorporates three components: loss of heterozygosity (LOH), telomeric allelic...

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Share to Allelic Imbalance
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Germ-Line Mutation

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Share to Loss of Heterozygosity

Share to Neoplasms, Germ Cell and Embryonal

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Share to Testicular Neoplasms

Source

Identifiers

PMID: 41831125
DOI: 10.1002/path.70047

Genes

MET
TP53
BRCA2
CDKN1B
HRAS
KRAS
MANEA
PRKDC
RNH1
ROS1
TWSG1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

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