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[Analysis of homologous recombination deficiency testing in ovarian cancer based on next-generation sequencing].

Zhonghua zhong liu za zhi [Chinese journal of oncology] - 23 Jul 2026

Li N M, Cheng H P, Zhou P, Li X H

Abstract excerpt

Objective: To comprehensively evaluate homologous recombination deficiency (HRD) status via next-generation sequencing (NGS) in ovarian cancer patients and analyze its correlations with clinicopathological features, microsatellite instability (MSI), and tumor mutational burden (TMB), thereby providing evidence for genetic risk assessment, PARP inhibitor (PARPi)-targeted therapy, and prognostic management....

Topics

Humans
Female
Ovarian Neoplasms
Middle Aged
High-Throughput Nucleotide Sequencing
BRCA2 Protein
Aged
Tumor Suppressor Protein p53
Microsatellite Instability
Adult
BRCA1 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Homologous Recombination

Cystadenocarcinoma, Serous

Germ-Line Mutation

Source

Identifiers

PMID: 42477931
DOI: 10.3760/cma.j.cn112152-20251013-00505

Genes

BRCA1
BRCA2
RAD51D
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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