Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of efflux pump channel of florfenicol for resistance-enhancing variant RE-CmeABC in Campylobacter.

The Journal of antimicrobial chemotherapy - 4 Mar 2026

Yao Hong, Li Wenjun, Chen Mengguo, Zhang Cheng, Zhao Wenbo, Li Hao, Li Shihong, Li Chenglong, Du Xiang-Dang, Fan Chen, Yang Longhua

Abstract excerpt

OBJECTIVES: This study aims to elucidate the molecular mechanism of enhanced florfenicol resistance mediated by the resistance-enhanced RE-CmeABC in Campylobacter, with a focus on the evolution of its efflux function. MATERIALS AND METHODS: The complex models of FFC with wild-type CmeB and RE-CmeB are constructed by molecular modelling methods, and the efflux channels and corresponding bottleneck residues are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Bacterial Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Campylobacter

Share to Drug Resistance, Bacterial

Share to Membrane Transport Proteins

Share to Microbial Sensitivity Tests

Share to Models, Molecular

Share to Mutation

Source

Identifiers

PMID: 41830323
DOI: 10.1093/jac/dkag047

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of efflux pump channel of florfenicol for resistance-enhancing variant RE-CmeABC in Campylobacter.PMID 41830323Read ↗

Mutation-based mechanism and evolution of the potent multidrug efflux pump RE-CmeABC in Campylobacter.Semantic proximity Read ↗

Antimicrobial Resistance in Campylobacter spp.Semantic proximity Read ↗

Tigecycline Resistance-Associated Mutations in the MepA Efflux Pump in Staphylococcus aureus.Semantic proximity Read ↗

Promoter regulatory mode evolution enhances the high multidrug resistance of tmexCD1-toprJ1Semantic proximity Read ↗

Evidence for multiple-antibiotic resistance in Campylobacter jejuni not mediated by CmeB or CmeF.Semantic proximity Read ↗

Correlation between gyrA and CmeR Box Polymorphism and Fluoroquinolone Resistance in Campylobacter jejuni Isolates in China.Semantic proximity Read ↗

Modulation of Membrane Influx and Efflux in Escherichia coli Sequence Type 131 Has an Impact on Bacterial Motility, Biofilm Formation, and Virulence in a Caenorhabditis elegans Model.Semantic proximity Read ↗

Genetic Basis and Functional Consequences of Differential Expression of the CmeABC Efflux Pump in Campylobacter jejuni Isolates.Semantic proximity Read ↗

Influence of a putative TonB-dependent receptor on cefiderocol susceptibility in clinical Enterobacter hormaechei isolates.Semantic proximity Read ↗

The synergistic action of reduced membrane permeability and antibiotic sequestration as a novel mechanism for carbapenem resistance in Campylobacter.Semantic proximity Read ↗

Identification of a novel G2073A mutation in 23S rRNA in amphenicol-selected mutants of Campylobacter jejuni.Semantic proximity Read ↗

High throughput screening identifies potential inhibitors targeting trimethoprim resistant DfrA1 protein in Klebsiella pneumoniae and Escherichia coliSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.