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Tigecycline Resistance-Associated Mutations in the MepA Efflux Pump in Staphylococcus aureus.

Microbiology spectrum - 17 Aug 2023

Huang Honghao, Wan Peng, Luo Xinyue, Lu Yixing, Li Xiaoshen, Xiong Wenguang, Zeng Zhenling

Abstract excerpt

Tigecycline is an important antibacterial drug for treating infection by clinical multidrug-resistant bacteria, and tigecycline-resistant Staphylococcus aureus (TRSA) has been increasingly reported in recent years. Notably, only rpsJ and mepA are associated with the tigecycline resistance of S. aureus. The mepA gene encodes MepA efflux pumps, and the overexpression of mepA has been confirmed to be directly...

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Identifiers

PMID: 37432114
DOI: 10.1128/spectrum.00634-23
PMCID: PMC10434020

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