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Article

Mutations in BRCA1, BRCA2 and other breast and ovarian cancer susceptibility genes in Central and South American populations.

Biological research - 6 Oct 2017

Jara Lilian, Morales Sebastian, de Mayo Tomas, Gonzalez-Hormazabal Patricio, Carrasco Valentina, Godoy Raul

Abstract excerpt

Breast cancer (BC) is the most common malignancy among women worldwide. A major advance in the understanding of the genetic etiology of BC was the discovery of BRCA1 and BRCA2 (BRCA1/2) genes, which are considered high-penetrance BC genes. In non-carriers of BRCA1/2 mutations, disease susceptibility may be explained of a small number of mutations in BRCA1/2 and a much higher proportion of mutations in...

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Source

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Identifiers

PMID: 28985766
DOI: 10.1186/s40659-017-0139-2
PMCID: PMC6389095

Genes

BRCA1
BRCA2
ATM
BARD1
FGFR2
GSTM1
MTHFR
PALB2
RAD51
TOX3
XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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