Article
Germline Pathogenic Variants in HER2-Positive Breast Cancer: Spectrum and Clinical Implications in a High-Risk Chinese Cohort.
Cancer medicine - 1 May 2026
Zhou Lijia, Ni Mengqian, Yang Anli, Zhou Qingru, Wang Daining, Dun Shu, Xu Fei, Huang Jiajia, Bi Xiwen, Xia Wen, Hong Ruoxi, Zheng Qiufan, Chen Meiting, Jiang Kuikui, Tang Jun, Wang Xi, Yuan Zhongyu, Wang Shusen, Shi Yanxia, Wang Fang, An Xin
Abstract excerpt
OBJECTIVE: Hereditary cancer risk assessment has predominantly focused on HER2-negative breast cancer (BC), with limited characterization of germline pathogenic variants (GPVs) in HER2-positive disease. This study aimed to delineate the prevalence, clinicopathological correlates, and clinical implications of GPVs in a cohort of HER2-positive BC patients. METHODS: We retrospectively reviewed BC patients who had...
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