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Article

Small cell lung cancer transdifferentiation: not a negligible phenomenon.

Current opinion in oncology - 1 Jan 2026

Horvath Lilla, Boettiger Kristiina, Megyesfalvi Zsolt, Döme Balázs, Aigner Clemens, Horváth-Rózsás Anita, Berta Judit

Abstract excerpt

PURPOSE OF REVIEW: Small cell lung cancer (SCLC), particularly its transdifferentiated form, is highly aggressive and has a poor prognosis. The diagnosis of SCLC transdifferentiation is challenging, as repeat biopsies are often not clinically feasible and few noninvasive predictors of this neuroendocrine transformation have been identified to date. RECENT FINDINGS: Some retrospective studies and case reports have...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41263473
DOI: 10.1097/CCO.0000000000001205

Genes

EGFR
ALK
RET

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