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Article

APOE ε4 carriage is associated with olfactory-hippocampal tract functional connectivity.

Brain imaging and behavior - 13 Mar 2026

Ikuta Toshikazu, Bither Taylor

Abstract excerpt

Olfactory dysfunction often emerges before cognitive symptoms and may signal early vulnerability to neurodegenerative processes. This study examined whether genetic risk, specifically the presence of the epsilon 4 allele in apolipoprotein E, is associated with altered functional connectivity between the hippocampus and olfactory regions. Resting-state functional imaging data from 126 participants (mean age = 71.8...

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Identifiers

PMID: 41820696
DOI: 10.1007/s11682-026-01109-x
PMCID: PMC12982280

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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