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Article

PI3K and MAPK Signaling Nodes Serve as Divergent Drivers of Phenotypic Plasticity in Cancer-Associated Fibroblasts in Colorectal Cancer.

Cancer research - 15 Jun 2026

Xia Zihan, De Vuyst Felix, Ernst Sam, Suwal Ujjwal, Vander Cruyssen Amélie, Rappu Pekka, Heino Jyrki, Dedeyne Sándor, Ceelen Wim, Craciun Ligia, Demetter Pieter, Hendrix An, De Wever Olivier

Abstract excerpt

Cancer-associated fibroblasts (CAF) exhibit phenotypic heterogeneity with each functional state playing critical roles in tumor progression. Notably, subtypes like inflammatory CAFs (iCAF), characterized by increased chemokine/cytokine secretion, and myofibroblast-like CAFs (myCAF), characterized by enhanced extracellular matrix (ECM) deposition and increased actomyosin contractility, can undergo phenotypic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41817574
DOI: 10.1158/0008-5472.CAN-25-0766
PMCID: PMC13266349

Genes

FGF2
FGFR1
JAK1
JAK2
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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