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Article

A Wnt-Induced Phenotypic Switch in Cancer-Associated Fibroblasts Inhibits EMT in Colorectal Cancer.

Cancer research - 15 Dec 2020

Mosa Mohammed H, Michels Birgitta E, Menche Constantin, Nicolas Adele M, Darvishi Tahmineh, Greten Florian R, Farin Henner F

Abstract excerpt

Tumor progression is recognized as a result of an evolving cross-talk between tumor cells and their surrounding nontransformed stroma. Although Wnt signaling has been intensively studied in colorectal cancer, it remains unclear whether activity in the tumor-associated stroma contributes to malignancy. To specifically interfere with stromal signals, we generated Wnt-independent tumor organoids that secrete the Wnt...

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Identifiers

PMID: 33055221
DOI: 10.1158/0008-5472.CAN-20-0263

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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