KANN: estimation of genetic ancestry profiles by nearest neighbor regression.

Abstract excerpt

State-of-the-art methods for inferring individual-level genetic ancestry are based on statistical models for haplotype data. Unfortunately, these methods are computationally demanding, making them impractical for biobank-scale analyses. In this paper, we describe KANN, an efficient k-nearest neighbor regression method for individual-level ancestry estimation with respect to predefined source populations using...

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