Article
Ancestry estimation and control of population stratification for sequence-based association studies.
Nature genetics - 1 Apr 2014
Wang Chaolong, Zhan Xiaowei, Bragg-Gresham Jennifer, Kang Hyun Min, Stambolian Dwight, Chew Emily Y, Branham Kari E, Heckenlively John, Fulton Robert, Wilson Richard K, Mardis Elaine R, Lin Xihong, Swaroop Anand, Zöllner Sebastian, Abecasis Gonçalo R
Abstract excerpt
Estimating individual ancestry is important in genetic association studies where population structure leads to false positive signals, although assigning ancestry remains challenging with targeted sequence data. We propose a new method for the accurate estimation of individual genetic ancestry, based on direct analysis of off-target sequence reads, and implement our method in the publicly available LASER...
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