Evaluating genetic-ancestry inference from single-cell transcriptomic datasets

Abstract excerpt

Characterizing the ancestry of donors in single-cell transcriptomic studies is crucial to ensure genetic homogeneity, reduce biases in analyses, identify ancestry-specific regulatory mechanisms and their downstream roles in disease, and ensure that existing datasets are representative of human genetic diversity. While these datasets are now widely available, information on the ancestry of donors is often missing,...

Topics

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• Gene Expression Profiling
• Genome, Human
• Genomics
• Neoplasms
• Polymorphism, Single Nucleotide
• Single-Cell Analysis
• Single-Cell Gene Expression Analysis
• Transcriptome

Identifiers and source

Literature Corpus work

c03ce944-27c6-5f0b-85a7-1e4fe0fcddba

DOI

10.1101/2025.03.25.645175