Article
Ancestry inference using reference labeled clusters of haplotypes.
BMC bioinformatics - 25 Sept 2021
Wang Yong, Song Shiya, Schraiber Joshua G, Sedghifar Alisa, Byrnes Jake K, Turissini David A, Hong Eurie L, Ball Catherine A, Noto Keith
Abstract excerpt
BACKGROUND: We present ARCHes, a fast and accurate haplotype-based approach for inferring an individual's ancestry composition. Our approach works by modeling haplotype diversity from a large, admixed cohort of hundreds of thousands, then annotating those models with population information from reference panels of known ancestry. RESULTS: The running time of ARCHes does not depend on the size of a reference panel...
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