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Article

No influence of brain-derived neurotrophic factor (BDNF) polymorphisms on treatment response in a naturalistic sample of patients with major depression.

European archives of psychiatry and clinical neuroscience - 1 Aug 2013

Musil Richard, Zill Peter, Seemüller Florian, Bondy Brigitta, Obermeier Michael, Spellmann Ilja, Bender Wolfram, Adli Mazda, Heuser Isabella, Zeiler Joachim, Gaebel Wolfgang, Maier Wolfgang, Rietschel Marcella, Rujescu Dan, Schennach Rebecca, Möller Hans-Jürgen, Riedel Michael

Abstract excerpt

The role of the brain-derived neurotrophic factor (BDNF) in the pathophysiology of major depressive disorder (MDD) remains to be elucidated. Recent post hoc analyses indicated a potential association of three polymorphisms in the BDNF gene with worse treatment outcome in patients with the subtype of melancholic depression. We aimed at replicating these findings in a German naturalistic multicenter follow-up....

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Antidepressive Agents
Brain-Derived Neurotrophic Factor
Depressive Disorder, Major
Follow-Up Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Association Studies

Pharmacogenetics

Polymorphism, Single Nucleotide

Statistics, Nonparametric

Source

Identifiers

PMID: 22965830
DOI: 10.1007/s00406-012-0364-1

Genes

BDNF

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