Article
Brain-derived neurotrophic factor gene polymorphisms: influence on treatment response phenotypes of major depressive disorder.
International clinical psychopharmacology - 1 Jan 2011
Kocabas Neslihan Aygun, Antonijevic Irina, Faghel Carole, Forray Carlos, Kasper Siegfried, Lecrubier Yves, Linotte Sylvie, Massat Isabelle, Mendlewicz Julien, Noro Magali, Montgomery Stuart, Oswald Pierre, Snyder Lenore, Zohar Joseph, Souery Daniel
Abstract excerpt
Brain-derived neurotrophic factor (BDNF), a member of the nerve growth factor family of neurotrophins, has pivotal roles in neuronal survival, proliferation, and synaptic plasticity in the brain. Both clinical and pharmacological studies have implicated the common single nucleotide polymorphism (SNP) at position 196, Val66Met in the pathophysiology of major depressive disorder (MDD), and antidepressant response....
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