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Article

Serum brain-derived neurotrophic factor, Val66Met polymorphism and open-label SSRI treatment response in Major Depressive Disorder.

Psychoneuroendocrinology - 1 Jul 2024

Smit Anna J T, Wu Gwyneth W Y, Rampersaud Ryan, Reus Victor I, Wolkowitz Owen M, Mellon Synthia H

Abstract excerpt

BACKGROUND: Brain-derived neurotrophic factor (BDNF) has been implicated in the therapeutic action of antidepressants and possibly in the pathophysiology of Major Depressive Disorder (MDD). Clinical studies of peripheral blood levels of BDNF in MDD have provided conflicting results, and there are also conflicting reports regarding the predictive value of peripheral BDNF levels for antidepressant treatment...

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Alleles
Antidepressive Agents
Brain-Derived Neurotrophic Factor
Genotype
Major Depressive Disorder

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Selective Serotonin Reuptake Inhibitors

Treatment Outcome

Source

Identifiers

PMID: 38636352
DOI: 10.1016/j.psyneuen.2024.107045

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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