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Article

Insights into inherited genetic variations and genetic ancestry of patients with high-risk melanoma.

Melanoma research - 1 Jun 2026

Tarhini Ahmad A, Khaksar Mohammad Ali, Chen Zhihua, Lee Sandra J, Hodi F Stephen, Li Tingyi, Monteiro Alvaro N, Streicher Howard, Sondak Vernon K, Wang Xuefeng, Kirkwood John M, Kanetsky Peter A

Abstract excerpt

Host genetic ancestry plays an important role in shaping somatic mutation landscapes and may influence therapeutic outcomes as well as the risk of developing treatment-related adverse events. As genetic ancestry has been associated with differential susceptibility to melanoma subtypes, distinct somatic mutation frequencies and variable responses to immune checkpoint inhibitors warrant further investigation. This...

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PMID: 41812038
DOI: 10.1097/CMR.0000000000001087
PMCID: PMC13254891

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