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Article

Association of genetic ancestry with molecular tumor profiles in colorectal cancer.

Genome medicine - 13 Aug 2024

Rhead Brooke, Hein David M, Pouliot Yannick, Guinney Justin, De La Vega Francisco M, Sanford Nina N

Abstract excerpt

BACKGROUND: There are known disparities in incidence and outcomes of colorectal cancer (CRC) by race and ethnicity. Some of these disparities may be mediated by molecular changes in tumors that occur at different rates across populations. Genetic ancestry is a measure complementary to race and ethnicity that can overcome missing data issues and better capture genetic similarity in admixed populations. We aimed to...

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Adenomatous Polyposis Coli Protein
Aged
Biomarkers, Tumor
Class I Phosphatidylinositol 3-Kinases
Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins B-raf

Proto-Oncogene Proteins p21(ras)

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Identifiers

PMID: 39138508
DOI: 10.1186/s13073-024-01373-w
PMCID: PMC11321170

Genes

BRAF
KRAS
APC
PIK3CA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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