Article
Circulating Tumor DNA Mutation Profiling by Targeted Next Generation Sequencing Provides Guidance for Personalized Treatments in Multiple Cancer Types.
Scientific reports - 3 Apr 2017
Shu Yongqian, Wu Xue, Tong Xiaoling, Wang Xiaonan, Chang Zhili, Mao Yu, Chen Xiaofeng, Sun Jing, Wang Zhenxin, Hong Zhuan, Zhu Liangjun, Zhu Chunrong, Chen Jun, Liang Ying, Shao Huawu, Shao Yang W
Abstract excerpt
Cancer is a disease of complex genetic alterations, and comprehensive genetic diagnosis is beneficial to match each patient to appropriate therapy. However, acquisition of representative tumor samples is invasive and sometimes impossible. Circulating tumor DNA (ctDNA) is a promising tool to use as a non-invasive biomarker for cancer mutation profiling. Here we implemented targeted next generation sequencing (NGS)...
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