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Article

Genetic subtraction reveals divergent pathways and targets in anxiety-related and anxiety-independent TMD.

The journal of headache and pain - 9 Mar 2026

Cao Yu, Yang Xin, Svensson Peter, Chung Wen Raymond Wong, Han Sng Timothy Jie, Islam Intekhab, Han Wei, Feng Xingmei, Hou Bozhi, Li Yuehua, Zheng Lei

Abstract excerpt

BACKGROUND: Temporomandibular disorders (TMD) show substantial clinical and genetic overlap with anxiety, yet it remains unclear whether TMD risk reflects shared anxiety-related liability or distinct anxiety-independent genetic mechanisms. Disentangling these components is essential for understanding TMD heterogeneity beyond symptom-based classifications. METHODS: We applied GWAS-by-subtraction using genome-wide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41796324
DOI: 10.1186/s10194-026-02304-3
PMCID: PMC13081294

Genes

GPNMB
RAB27B
KLHL7
BTN1A1
CNTNAP5
PCLO
PRSS16

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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