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Brainwide Mendelian Randomization Study of Anxiety Disorders and Symptoms.

Biological psychiatry - 15 Apr 2024

Zanoaga Mihaela-Diana, Friligkou Eleni, He Jun, Pathak Gita A, Koller Dora, Cabrera-Mendoza Brenda, Stein Murray B, Polimanti Renato

Abstract excerpt

BACKGROUND: To gain insights into the role of brain structure and function on anxiety (ANX), we conducted a genetically informed investigation leveraging information from ANX genome-wide association studies available from the UK Biobank (n = 380,379), the FinnGen Program (n = 290,361), and the Million Veteran Program (n = 175,163) together with UK Biobank genome-wide data (n = 33,224) related to 3935 brain...

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Identifiers

PMID: 37967698
DOI: 10.1016/j.biopsych.2023.11.006
PMCID: PMC10978301

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