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Article

Comparative genomic landscape of primary and metastatic bladder urothelial carcinoma in a large-scale cohort.

International journal of clinical oncology - 1 May 2026

Ohtsu Akira, Otani Yusuke, Arai Seiji, Rogachevskaya Anna, Chin Vanessa D, Toyooka Shinichi, Suzuki Kazuhiro, Wei Wenyi, Tanaka Atsushi

Abstract excerpt

BACKGROUND: Metastatic bladder urothelial carcinoma has poor survival, and large comparative genomic studies using uniform targeted sequencing of paired primary and metastatic lesions remain limited. We compared gene- and pathway-level alterations between primary and metastatic tumors METHODS: We analyzed 2,880 bladder urothelial carcinoma samples (2,305 primary; 575 metastatic) from 2,343 patients profiled with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41795757
DOI: 10.1007/s10147-026-03005-2
PMCID: PMC13347192

Genes

TP53
ERCC2
FGFR3
IMPACT
KDM6A
STAG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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